E-Cadherin loss associated with EMT promotes radioresistance in human tumor cells

Jan Theys, Barry Jutten, R. Habets, +6

Radiotherapy and Oncology

Tumor BiologyOncologyHuman Tumor CellsEmt Promotes RadioresistanceMedicine +7

Repeated cycles of Clostridium-directed enzyme prodrug therapy result in sustained antitumour effects in vivo

Jan Theys, Oliver Pennington, Ludwig J. Dubois, +10

British Journal of Cancer

EngineeringAntibiotic AdjuvantGene Delivery VectorPharmacotherapyAntimicrobial Chemotherapy +16

Lysine 63-Polyubiquitination Guards against Translesion Synthesis–Induced Mutations

Roland K. Chiu, J Brun, Chantal H.M.A. Ramaekers, +5

PLoS Genetics

Hypoxia-activated prodrugs and (lack of) clinical progress: The need for hypoxia-based biomarker patient selection in phase III clinical trials

Linda Spiegelberg, Ruud Houben, Raymon Niemans, +8

Clinical and Translational Radiation Oncology

Clinical ProgressPharmacotherapyTumor BiologyOxidative StressTranslational Medicine +17

Specific targeting of cytosine deaminase to solid tumors by engineered Clostridium acetobutylicum

Jan Theys, Willy Landuyt, Sandra Nuyts, +4

Cancer Gene Therapy

Cytosine DeaminaseEngineeringBiochemistrySolid TumorsNatural Sciences +10

Radio-responsive recA promoter significantly increases TNFα production in recombinant clostridia after 2 Gy irradiation

Sandra Nuyts, Lieve Van Mellaert, Jan Theys, +4

Gene Therapy

Tnfα ProductionNatural SciencesMolecular BiologyRadio-responsive Reca PromoterGy Irradiation +2

Colonisation ofClostridiumin the body is restricted to hypoxic and necrotic areas of tumours

Philippe Lambin, Jan Theys, Willy Landuyt, +9

Anaerobe

Surgical PathologyHistopathologyGastroenterologyPathologyNecrotic Areas +4

Regulated Proteolysis of NOTCH2 and NOTCH3 Receptors by ADAM10 and Presenilins

Arjan J. Groot, R. Habets, Sanaz Yahyanejad, +4

Molecular and Cellular Biology

Transcriptional RegulationProtein FunctionSignal TransductionDevelopmental BiologySignaling Pathway +11

Development of a flexible and potent hypoxia-inducible promoter for tumor-targeted gene expression in attenuated s<i>almonella</i>

Asferd Mengesha, Ludwig J. Dubois, Philippe Lambin, +4

Cancer Biology & Therapy

In vivo antitumor effect of vascular targeting combined with either ionizing radiation or anti-angiogenesis treatment

Willy Landuyt, Bisan Ahmed, Sandra Nuyts, +7

International Journal of Radiation Oncology*Biology*Physics

Vivo Antitumor EffectOncologyAngiogenesisRadiation TherapyAnti-angiogenesis Treatment +7