Jan Theys

E-Cadherin loss associated with EMT promotes radioresistance in human tumor cells

Jan Theys, Barry Jutten, R. Habets et al. · Radiotherapy and Oncology · 2011 · 220 citations

Medicine, Cell Biology, Oncology +12

Repeated cycles of Clostridium-directed enzyme prodrug therapy result in sustained antitumour effects in vivo

Jan Theys, Oliver Pennington, Ludwig J. Dubois et al. · British Journal of Cancer · 2006 · 138 citations · Full text

Pharmacy, Bioengineering, Biotechnology +15

Lysine 63-Polyubiquitination Guards against Translesion Synthesis–Induced Mutations

Roland K. Chiu, J Brun, Chantal H.M.A. Ramaekers et al. · PLoS Genetics · 2006 · 122 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Hypoxia-activated prodrugs and (lack of) clinical progress: The need for hypoxia-based biomarker patient selection in phase III clinical trials

Linda Spiegelberg, Ruud Houben, Raymon Niemans et al. · Clinical and Translational Radiation Oncology · 2019 · 115 citations · Full text

Medicine, Oncology, Pharmacology +16

Specific targeting of cytosine deaminase to solid tumors by engineered Clostridium acetobutylicum

Jan Theys, Willy Landuyt, Sandra Nuyts et al. · Cancer Gene Therapy · 2001 · 108 citations · Full text

Life Sciences, Molecular Biology, Oncology +11