Chitosan oligosaccharides prevent doxorubicin-induced oxidative stress and cardiac apoptosis through activating p38 and JNK MAPK mediated Nrf2/ARE pathway

Identification of the molecular basis of doxorubicin-induced cardiotoxicity

Sui Zhang, Xiaobing Liu, Tasneem Bawa‐Khalfe et al. · Nature Medicine · 2012 · 1.9K citations

Medicine, Biochemistry, Pharmacology +14

A clinicopathologic analysis of adriamycin cardiotoxicity

Edward A. Lefrak, Jan Piťha, Sidney Rosenheim et al. · Cancer · 1973 · 1.6K citations

Medicine, Cardiology, Pharmacology +16

Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation

Yoshihiko Ichikawa, Mohsen Ghanefar, Marina Bayeva et al. · Journal of Clinical Investigation · 2014 · 875 citations · Full text

Medicine, Cardiology, Pharmacology +17

Phosphorylation of Nrf2 at Multiple Sites by MAP Kinases Has a Limited Contribution in Modulating the Nrf2-Dependent Antioxidant Response

Zheng Sun, Zheping Huang, Donna D. Zhang · PLoS ONE · 2009 · 361 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Induction of the Nrf2-driven Antioxidant Response Confers Neuroprotection during Mitochondrial Stress in Vivo

Andy Y. Shih, Sophie Imbeault, Vilte Barakauskas et al. · Journal of Biological Chemistry · 2005 · 270 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17