Macrocyclization of peptidoarylacetamides with self-assembly properties through late-stage palladium-catalyzed C(sp ² )▬H olefination

Abstract

)▬H olefination. In this protocol, peptide backbones act as internal directing groups and enable facile preparation of diverse cyclic peptides that are difficult to synthesize by conventional macrolactamization. Furthermore, we show that the incorporation of aryl-alkene cross-link in the backbone constrains cyclic peptides into conformations for self-assembly.