Concepedia

Peptide Macrocyclization

Peptide Macrocyclization is a chemical methodology in peptide chemistry that involves the intramolecular cyclization of linear peptides to form macrocyclic architectures, distinguished by the formation of a covalent bond between side chains or termini to constrain conformational flexibility and enhance biological stability.

397

Publications

18.7K

Citations

1.6K

Authors

415

Institutions

Publications per year

2017–2026

158

Parents

Publications

397

Application of Ring-Closing Metathesis to the Synthesis of Rigidified Amino Acids and Peptides

Scott J. Miller, Helen E. Blackwell, Robert H. Grubbs · Journal of the American Chemical Society · 1996 · 431 citations

, , +16

Butelase 1 is an Asx-specific ligase enabling peptide macrocyclization and synthesis

Giang K. T. Nguyen, Shujing Wang, Yibo Qiu et al. · Nature Chemical Biology · 2014 · 430 citations

, , +9

Microcin J25 Has a Threaded Sidechain-to-Backbone Ring Structure and Not a Head-to-Tail Cyclized Backbone

K. Johan Rosengren, Richard J. Clark, Norelle L. Daly et al. · Journal of the American Chemical Society · 2003 · 265 citations

, , +14

A general strategy for synthesis of cyclophane-braced peptide macrocycles via palladium-catalysed intramolecular sp3 C−H arylation

Xuekai Zhang, Gang Lü, Meng Sun et al. · Nature Chemistry · 2018 · 244 citations

, , +12

Structure and biosynthesis of a macrocyclic peptide containing an unprecedented lysine-to-tryptophan crosslink

Kelsey R. Schramma, Leah B. Bushin, Mohammad R. Seyedsayamdost · Nature Chemistry · 2015 · 237 citations · Full text

, , +13

1–5 of 397

Authors

1.6K

  1. AK
    Andrei K. Yudin

    University of Toronto, Canada

    18 publications · 1K citations

    17

    h-index

  2. HW
    Huan Wang

    Nanjing University, China

    13 publications · 731 citations

    13

    h-index

  3. LA
    Ludger A. Wessjohann

    Leibniz Institute of Plant Biochemistry, Germany

    10 publications · 365 citations

    10

    h-index

  4. DG
    Daniel G. Rivera

    University of Havana, Cuba

    10 publications · 365 citations

    10

    h-index

  5. BL
    Bradley L. Pentelute

    Massachusetts Institute of Technology, United States

    8 publications · 586 citations

    8

    h-index

1–5 of 1.6K

Institutions

415

  1. University of Toronto

    Toronto, Canada

    17 h-index

    79 publications

    4K citations

  2. Scripps Research Institute

    San Diego, United States

    16 h-index

    55 publications

    4K citations

  3. Nanjing University

    Nanjing, China

    14 h-index

    77 publications

    4.9K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    13 h-index

    44 publications

    1.6K citations

  5. University of Havana

    Havana, Cuba

    10 h-index

    30 publications

    1.1K citations

  6. Leibniz Institute of Plant Biochemistry

    Halle, Germany

    10 h-index

    41 publications

    1.5K citations

  7. Nanyang Technological University

    Singapore, Singapore

    10 h-index

    36 publications

    4.6K citations

  8. Massachusetts Institute of Technology

    Cambridge, United States

    9 h-index

    38 publications

    2.7K citations

1–8 of 415

Venues

  1. Journal of the American Chemical Society

    JACS · 57 publications · 4.8K citations

    41

    h-index

  2. Organic Letters

    OL · 41 publications · 1.7K citations

    26

    h-index

  3. The Journal of Organic Chemistry

    JOC · 29 publications · 1.1K citations

    22

    h-index

  4. Angewandte Chemie International Edition

    23 publications · 1.8K citations

    20

    h-index

  5. Chemistry - A European Journal

    19 publications · 584 citations

    16

    h-index

1–5