Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells

Integrating single-cell transcriptomic data across different conditions, technologies, and species

Andrew Butler, Paul Hoffman, Peter Smibert et al. · Nature Biotechnology · 2018 · 14.1K citations · Full text

Engineering, Genetics, Multiomics +17

Universal sample preparation method for proteome analysis

Jacek R. Wiśniewski, Alexandre Zougman, Nagarjuna Nagaraj et al. · Nature Methods · 2009 · 8.5K citations

Proteomic Technology, Biochemistry, Proteome Analysis +7

Reversed graph embedding resolves complex single-cell trajectories

Xiaojie Qiu, Qi Mao, Ying Tang et al. · Nature Methods · 2017 · 5K citations · Full text

Graph Theory, Medicine, Biological Network +6

Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry

Joshua E. Elias, Steven P. Gygi · Nature Methods · 2007 · 4K citations

Natural Sciences, Large-scale Protein Identifications, Medicine +12

Vascularized and functional human liver from an iPSC-derived organ bud transplant

Takanori Takebe, Keisuke Sekine, Masahiro Enomura et al. · Nature · 2013 · 2.1K citations

Regenerative Medicine, Translational Medicine, Transplantation +13