Concepedia

FXR deficiency alters bile acid pool composition and exacerbates chronic alcohol induced liver injury

Bo Kong, Min Zhang, Mingxing Huang, Daniel Rizzolo, Laura E. Armstrong, Justin D. Schumacher, Monica D. Chow, Yi‐Horng Lee, Grace L. Guo

Digestive and Liver Disease · 2019 · 73 citations · 27 references

DOI

Concepts

References

27

Identification of a Nuclear Receptor for Bile Acids

Makoto Makishima, Arthur Y. Okamoto, Joyce J. Repa et al. · Science · 1999 · 2.7K citations

, , +17

Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

Derek J. Parks, Steven G. Blanchard, Randy K. Bledsoe et al. · Science · 1999 · 2.2K citations

, , +17

Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis

Christopher J. Sinal, Masahiro Tohkin, Masaaki Miyata et al. · Cell · 2000 · 1.8K citations · Full text

, , +12

Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR

Haibo Wang, Jasmine Chen, Kevin Hollister et al. · Molecular Cell · 1999 · 1.6K citations · Full text

, , +12

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

Mitsuhiro Watanabe, Sander M. Houten, Li Wang et al. · Journal of Clinical Investigation · 2004 · 1.4K citations · Full text

, , +17