Concepedia

Restriction of hepatitis B virus replication by c-Abl–induced proteasomal degradation of the viral polymerase

Lidan Hou, Jie Zhao, Shaobing Gao, Tong Ji, Tianyu Song, Yining Li, Jingjie Wang, Chenlu Geng, Min Long, Jiang Chen,

Science Advances · 2019 · 29 citations · 35 references

DOIFull text

Open access

Concepts

Abstract

axis or pharmaceutical inhibition of this process stabilizes HBV polymerase protein and increases viral loads in HBV-infected liver cancer cell lines. Our study reveals a kinase-dependent activation of CRL4 ubiquitin ligase that can be targeted for blocking HBV replication.

References

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