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First-in-human phase I study of the bromodomain and extraterminal motif inhibitor BAY 1238097: emerging pharmacokinetic/pharmacodynamic relationship and early termination due to unexpected toxicity

Pharmacological StudyMedicineImmunologyUnexpected ToxicityEarly TerminationPharmacotherapyPharmacologyPharmacokinetic/pharmacodynamic RelationshipPharmacokineticsDrug Discovery