Phellodendrine chloride suppresses proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

Jaekyoung Son, Costas A. Lyssiotis, Haoqiang Ying et al. · Nature · 2013 · 2K citations · Full text

Medicine, Cancer Biology, Oncology +12

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

Cosimo Commisso, Shawn M. Davidson, Rengin G. Soydaner-Azeloglu et al. · Nature · 2013 · 1.7K citations

Life Sciences, Biochemistry, Molecular Biology +13

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

Jurre J. Kamphorst, Michel Nofal, Cosimo Commisso et al. · Cancer Research · 2015 · 880 citations · Full text

Medicine, Cancer Biology, Oncology +17

ROS inhibitor <i>N</i>-acetyl-<scp>L</scp>-cysteine antagonizes the activity of proteasome inhibitors

Marianna Halasi, Ming Wang, Tanmay Chavan et al. · Biochemical Journal · 2013 · 372 citations

Life Sciences, Biochemistry, Pharmacology +12

Cadmium Induces Apoptosis in Pancreatic β-Cells through a Mitochondria-Dependent Pathway: The Role of Oxidative Stress-Mediated c-Jun N-Terminal Kinase Activation

Kai‐Chih Chang, Ching-Cheng Hsu, Shing‐Hwa Liu et al. · PLoS ONE · 2013 · 148 citations · Full text

Pharmacy, Biochemistry, Toxicology +17