Jujuboside A promotes Aβ clearance and ameliorates cognitive deficiency in Alzheimer's disease through activating Axl/HSP90/PPARγ pathway

Mu Zhang, Qian Cheng, Zu‐Guo Zheng, +11

Theranostics

Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway

Zu‐Guo Zheng, Si-Tong Zhu, Huimin Cheng, +11

Autophagy

Inhibition of HSP90β Improves Lipid Disorders by Promoting Mature SREBPs Degradation via the Ubiquitin-proteasome System

Zu‐Guo Zheng, Xin Zhang, Xiao-Xiao Liu, +19

Theranostics

w09, a novel autophagy enhancer, induces autophagy-dependent cell apoptosis via activation of the EGFR-mediated RAS-RAF1-MAP2K-MAPK1/3 pathway

Pinghu Zhang, Zu‐Guo Zheng, Ling Li, +9

Autophagy

Gastric Cancer CellsChemoprevention StrategyApoptosisImmunologyCell Death +16

Dual targeting of SREBP2 and ERRα by carnosic acid suppresses RANKL-mediated osteoclastogenesis and prevents ovariectomy-induced bone loss

Zu‐Guo Zheng, Huimin Cheng, Yaping Zhou, +5

Cell Death and Differentiation

Carnosic AcidSignal TransductionOrthopaedic SurgeryCell SignalingDual Targeting +6

Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1,2-DAG-PKCε signaling axis

Zu‐Guo Zheng, Yin-Yue Xu, Wenping Liu, +9

Cell Metabolism

Metabolic SyndromeSignal TransductionMolecular PhysiologySignaling PathwaySn-1,2-dag-pkcε Signaling Axis +10

Anhydroicaritin, a SREBPs inhibitor, inhibits RANKL-induced osteoclastic differentiation and improves diabetic osteoporosis in STZ-induced mice

Zu‐Guo Zheng, Xin Zhang, Yaping Zhou, +7

European Journal of Pharmacology

Diabetic OsteoporosisSclerostinBone Morphogenic ProteinMedicineStz-induced Mice +8

Anhydroicaritin improves diet-induced obesity and hyperlipidemia and alleviates insulin resistance by suppressing SREBPs activation

Zu‐Guo Zheng, Yaping Zhou, Xin Zhang, +10

Biochemical Pharmacology

Insulin ResistanceNutritionObesityMetabolic SyndromeSrebps Activation +11

Optimization of mixture proportions in ternary low-heat Portland cement-based cementitious systems with mortar blends based on projection pursuit regression

Jingwei Gong, Chunmeng Jiang, Xinjun Tang, +2

Construction and Building Materials

Materials ScienceMortar BlendsCementationEngineeringProjection Pursuit Regression +5

Phellodendrine chloride suppresses proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis

Pyone Myat Thu, Zu‐Guo Zheng, Yaping Zhou, +7

European Journal of Pharmacology

Pancreatic CancerChemoprevention StrategyBiochemistryPhellodendrine ChlorideMedicine +7