Cell Reports · 2019 · 67 citations · 38 references
Life SciencesCancer BiologyOncologyCellular MetabolismMetabolismMolecular OncologyCancer MetabolismMetabolic ReprogrammingMetabolic Reprogramming In CancerRedox MetabolismSynthetic LethalitySynthetic Lethality In CancerFumarate Hydratase DeficiencyGlycolysisHereditary LeiomyomatosisMetabolic Synthetic LethalityOxidative Phosphorylation DefectsOxidative Phosphorylation DeficiencyOxidative Phosphorylation ImpairmentOxphos Deficiency
/NADPH ratio to disrupt redox homeostasis. Furthermore, in the OXPHOS-proficient context, blocking OXPHOS using the small-molecule inhibitor IACS-010759 enhances sensitivity to PGD inhibition in vitro and in vivo. Together, our study reveals a dependency on PGD in OXPHOS-deficient tumors that might inform therapeutic intervention in specific patient populations.
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Features and development of <i>Coot</i>
Paul Emsley, Bernhard Lohkamp, W. G. Scott et al. · Acta Crystallographica Section D Biological Crystallography · 2010 · 29.6K citations · Full text