Tracing metabolic fluxes using mass spectrometry: Stable isotope-resolved metabolomics in health and disease

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

Edward T. Chouchani, Victoria R. Pell, Edoardo Gaude et al. · Nature · 2014 · 2.7K citations · Full text

Inflammation, Mitochondrial Function, Biochemistry +9

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

Haoqiang Ying, Alec C. Kimmelman, Costas A. Lyssiotis et al. · Cell · 2012 · 2K citations · Full text

Pancreatic Cancer, Oncogenic Agent, Medicine +7

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

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Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

Christian M. Metallo, Paulo A. Gameiro, Eric L. Bell et al. · Nature · 2011 · 1.7K citations · Full text

Biochemistry, Redox Regulator, Hypoxia (Medicine) +5

Glucose feeds the TCA cycle via circulating lactate

Sheng Hui, Jonathan M. Ghergurovich, Raphael J. Morscher et al. · Nature · 2017 · 1.6K citations · Full text

Nutrition, Energy Metabolism, Biochemistry +7