Concepedia

5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute Parkinson's disease in mice by inhibiting the NLRP3 inflammasome and protects PC12 cells against oxidative stress

Lili Xu, Yufeng Wu, Cuicui Li, Zhen Dai, Qidong You, Zhengyu Jiang, Bin Di

Free Radical Biology and Medicine · 2019 · 71 citations · 17 references

DOI

Concepts

References

17

Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte

Pei‐Chun Chen, Marcelo R. Vargas, Amar K. Pani et al. · Proceedings of the National Academy of Sciences · 2009 · 579 citations · Full text

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The Proinflammatory Cytokines Interleukin-1beta and Tumor Necrosis Factor-Alpha Activate Serotonin Transporters

Chong-Bin Zhu, Randy Blakely, William A. Hewlett · Neuropsychopharmacology · 2006 · 547 citations

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Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease

Honglei Chen, Eric J. Jacobs, Michael A. Schwarzschild et al. · Annals of Neurology · 2005 · 475 citations

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MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration

Eunju Lee, Inhwa Hwang, Sangjun Park et al. · Cell Death and Differentiation · 2018 · 449 citations · Full text

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Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease

Ana I. Rojo, Nadia G. Innamorato, Ana M. Martín‐Moreno et al. · Glia · 2009 · 373 citations

, , +17