New dammarane-type triterpenoid saponins from Panax notoginseng saponins

Abstract

Three new triterpenoid saponins (<b>1</b>-<b>3</b>) together with 25 known rare saponins (<b>4</b>-<b>28</b>) were isolated from PNS, except for the five main compounds (notoginsenoside R₁ and ginsenoside Rg₁, Rd, Re, and Rb₁). In addition, the HPLC fingerprint of PNS was established, and the peaks of the isolated compounds were marked. The study of chemical constituents and fingerprint was useful for the quality control of PNS. The study on antitumor activities showed that new Compound <b>2</b> exhibited significant inhibitory activity against the tested cell lines.