Concepedia

Role of human Keap1 S53 and S293 residues in modulating the binding of Keap1 to Nrf2

Shuangshuang Wei, Yechun Pei, Yuerong Wang, Huai Guan, Yonglin Huang, Tian Xing, Rodney W. Johnson, Dayong Wang

Biochimie · 2018 · 15 citations · 19 references

DOI

Concepts

References

19

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Ken Itoh, Nobunao Wakabayashi, Yasutake Katoh et al. · Genes & Development · 1999 · 3.6K citations · Full text

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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Albena T. Dinkova‐Kostova, W. David Holtzclaw, Robert N. Cole et al. · Proceedings of the National Academy of Sciences · 2002 · 1.9K citations · Full text

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A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression

Edward L. Huttlin, Mark P. Jedrychowski, Joshua E. Elias et al. · Cell · 2010 · 1.8K citations · Full text

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Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

Donna D. Zhang, Mark Hannink · Molecular and Cellular Biology · 2003 · 1.4K citations · Full text

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Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex

Donna D. Zhang, Shih‐Ching Lo, Janet V. Cross et al. · Molecular and Cellular Biology · 2004 · 1.2K citations

, , +15