Concepedia

The role of the PD-1/PD-L1 axis in macrophage differentiation and function during pregnancy

Yonghong Zhang, Lina Ma, Xiaohui Hu, Jinlu Ji, Gil Mor, Aihua Liao

Human Reproduction · 2018 · 157 citations · 34 references

DOI

Abstract

This study was supported by the National Nature Science Foundation of China (No. 81671490) and Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College, HUST (No. 5001519002). None of the authors has any conflict of interest to declare.

References

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Succinate is an inflammatory signal that induces IL-1β through HIF-1α

Gillian M. Tannahill, Annie M. Curtis, Juraj Adamik et al. · Nature · 2013 · 3.8K citations · Full text

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Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

Abhishek Jha, Stanley Ching‐Cheng Huang, Alexey Sergushichev et al. · Immunity · 2015 · 1.9K citations · Full text

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CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms

Richard V. Parry, Jens M. Chemnitz, Kenneth A. Frauwirth et al. · Molecular and Cellular Biology · 2005 · 1.9K citations · Full text

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The CD28 Signaling Pathway Regulates Glucose Metabolism

Kenneth A. Frauwirth, James L. Riley, Marian H. Harris et al. · Immunity · 2002 · 1.4K citations · Full text

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IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

Thomas Krausgruber, Katrina Blazek, Tim Smallie et al. · Nature Immunology · 2011 · 1.3K citations · Full text