Concepedia

β-Barrel outer membrane proteins suppress mTORC2 activation and induce autophagic responses

Anu Chaudhary, Cassandra Kamischke, Mara Leite, Melissa A. Altura, Loren Kinman, Hemantha D. Kulasekara, Marie-Pierre Blanc, Guoxing Wang, Cox Terhorst, Samuel I. Miller

Science Signaling · 2018 · 11 citations · 43 references

DOI

Concepts

Abstract

Typhimurium facilitated bacterial clearance. These data identify a specific cellular response mediated by bacterial and mitochondrial OMPs that can alter inflammatory responses and influence the killing of pathogens.

References

43

Methods in Mammalian Autophagy Research

Noboru Mizushima, Tamotsu Yoshimori, Beth Levine · Cell · 2010 · 4.5K citations · Full text

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p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

Geir Bjørkøy, Trond Lamark, Andreas Brech et al. · The Journal of Cell Biology · 2005 · 3.3K citations · Full text

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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Sven Geisler, Kira M. Holmström, Diana Skujat et al. · Nature Cell Biology · 2010 · 2.8K citations

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A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

Jochen Hampe, André Franke, Philip Rosenstiel et al. · Nature Genetics · 2006 · 1.9K citations

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Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

John D. Rioux, Ramnik J. Xavier, Kent D. Taylor et al. · Nature Genetics · 2007 · 1.8K citations · Full text

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