Autophagy in the Pathogenesis of Disease

Beth Levine, Guido Kroemer

Cell

Cell AutophagyMitophagyAutoimmune DiseaseAutoantibody ProductionPathogenesis +8

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

Yukihiro Kabeya

The EMBO Journal

Cell AutophagyAutophagosome MembranesAutophagyYeastLipophagy +7

Autophagy fights disease through cellular self-digestion

Noboru Mizushima, Beth Levine, Ana María Cuervo, +1

Nature

Cell AutophagyMitophagyAutoimmune DiseaseAutoantibody ProductionPathogenesis +6

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

Geir Bjørkøy, Trond Lamark, Andreas Brech, +5

The Journal of Cell Biology

The role of autophagy during the early neonatal starvation period

Akiko Kuma, Masahiko Hatano, Makoto Matsui, +6

Nature

NutritionMitophagyEnergy HomeostasisDevelopmental BiologyCell Autophagy +6

Impairment of starvation-induced and constitutive autophagy in <i>Atg7</i> -deficient mice

Masaaki Komatsu, Satoshi Waguri, Takashi Ueno, +10

The Journal of Cell Biology

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Brinda Ravikumar, Zdenek Berger, J. Eric Davies, +7

Nature Genetics

Cell AutophagyMitophagyMedicinePolyglutamine ExpansionsAutophagy +7

In Vivo Analysis of Autophagy in Response to Nutrient Starvation Using Transgenic Mice Expressing a Fluorescent Autophagosome Marker

Noboru Mizushima, Akitsugu Yamamoto, Makoto Matsui, +2

Molecular Biology of the Cell

MitophagyYeast Atg8Fluorescent Autophagosome MarkerApoptosisCell Death +17

Dissection of the Autophagosome Maturation Process by a Novel Reporter Protein, Tandem Fluorescent-Tagged LC3

Shunsuke Kimura, Takeshi Noda, Tamotsu Yoshimori

Autophagy

MitophagyMolecular BiologyCell AutophagyAutophagosome Maturation ProcessAutophagy +15

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

Xueping Qu, Jie Yu, Govind Bhagat, +9

Journal of Clinical Investigation