Combination treatment of acute myeloid leukemia cells with DNMT and HDAC inhibitors: predominant synergistic gene downregulation associated with gene body demethylation

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

Katherine B. Chiappinelli, Pamela L. Strissel, Alexis Desrichard et al. · Cell · 2015 · 2K citations · Full text

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Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

Elizabeth E. Cameron, Kurtis E. Bachman, Sanna Myöhänen et al. · Nature Genetics · 1999 · 1.9K citations

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Conserved role of intragenic DNA methylation in regulating alternative promoters

Alika K. Maunakea, Raman P. Nagarajan, Mikhail Bilenky et al. · Nature · 2010 · 1.8K citations

Medicine, Genetics, Molecular Biology +16

DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts

David Roulois, Helen Loo Yau, Rajat Singhania et al. · Cell · 2015 · 1.5K citations · Full text

Medicine, Molecular Biology, Oncology +13

Gene Body Methylation Can Alter Gene Expression and Is a Therapeutic Target in Cancer

Xiaojing Yang, Han Han, Daniel D. De Carvalho et al. · Cancer Cell · 2014 · 1.2K citations · Full text

Medicine, Molecular Biology, Oncology +12