GalNAc Conjugation Attenuates the Cytotoxicity of Antisense Oligonucleotide Drugs in Renal Tubular Cells

Feature point tracking and trajectory analysis for video imaging in cell biology

Ivo F. Sbalzarini, Petros Koumoutsakos · Journal of Structural Biology · 2005 · 1.4K citations · Full text

Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents

C.A. Stein, Jens Bo Hansen, Johnathan C. Lai et al. · Nucleic Acids Research · 2009 · 376 citations · Full text

Engineering, Molecular Biology, Gene Delivery +20

Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes

Erich Koller, Thomas M. Vincent, Alfred E. Chappell et al. · Nucleic Acids Research · 2011 · 275 citations · Full text

Immunology, Immunoediting, Molecular Biology +19

Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates

Ellen Marie Straarup, Niels Fisker, Maj Hedtjärn et al. · Nucleic Acids Research · 2010 · 244 citations · Full text

Properties of Cloned and Expressed Human RNase H1

Hongjiang Wu, Walt F. Lima, Stanley T. Crooke · Journal of Biological Chemistry · 1999 · 160 citations · Full text