Alfred E. Chappell

Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary<i>N</i>-acetyl galactosamine improves potency 10-fold in mice

Thazha P. Prakash, Mark J. Graham, Jinghua Yu et al. · Nucleic Acids Research · 2014 · 597 citations · Full text

Pharmacy, Molecular Pharmaceutics, Pharmacology +17

Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes

Erich Koller, Thomas M. Vincent, Alfred E. Chappell et al. · Nucleic Acids Research · 2011 · 279 citations · Full text

Life Sciences, Cancer Biology, Molecular Biology +16

Single-Stranded siRNAs Activate RNAi in Animals

Walt F. Lima, Thazha P. Prakash, Heather Murray et al. · Cell · 2012 · 257 citations · Full text

Life Sciences, Genetics, Molecular Biology +10

PHARMACOKINETICS OF A TUMOR NECROSIS FACTOR-α PHOSPHOROTHIOATE 2′-O-(2-METHOXYETHYL) MODIFIED ANTISENSE OLIGONUCLEOTIDE: COMPARISON ACROSS SPECIES

Richard S. Geary, Rosie Z. Yu, Tanya Watanabe et al. · Drug Metabolism and Disposition · 2003 · 162 citations

Pharmacy, Pharmacokinetics, Pharmacology +13

Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle

Thazha P. Prakash, Adam E. Mullick, Richard Lee et al. · Nucleic Acids Research · 2019 · 154 citations · Full text

Life Sciences, Biochemistry, Pharmacology +15