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Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors

Kongkai Zhu, Jiali Song, Hongrui Tao, Zhiqiang Cheng, Cheng‐Shi Jiang, Hua Zhang

Bioorganic & Medicinal Chemistry Letters · 2018 · 28 citations · 28 references

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28

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

Elayne Chan-Penebre, Kristy G. Kuplast, Christina R. Majer et al. · Nature Chemical Biology · 2015 · 546 citations

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The Methylosome, a 20S Complex Containing JBP1 and pICln, Produces Dimethylarginine-Modified Sm Proteins

Westley J. Friesen, Sergey Paushkin, Anastasia Wyce et al. · Molecular and Cellular Biology · 2001 · 405 citations · Full text

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Crystal structure of the human PRMT5:MEP50 complex

Stephen Antonysamy, Zahid Bonday, Robert M. Campbell et al. · Proceedings of the National Academy of Sciences · 2012 · 363 citations · Full text

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PRMT5 (Janus Kinase-binding Protein 1) Catalyzes the Formation of Symmetric Dimethylarginine Residues in Proteins

Tina L. Branscombe, Adam Frankel, Jin‐Hyung Lee et al. · Journal of Biological Chemistry · 2001 · 360 citations · Full text

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PRMT5 dimethylates R30 of the p65 subunit to activate NF-κB

Wei Han, Benlian Wang, Masaru Miyagi et al. · Proceedings of the National Academy of Sciences · 2013 · 235 citations · Full text

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