Concepedia

Radix <em>Tetrastigma hemsleyani</em> flavone exhibits antitumor activity in colorectal cancer via Wnt/β-catenin signaling pathway

Xiaowei Wu, Na Yu, Yuping Zhang, Yuan-Ning Ye, Wen-Rong Sun, Lei Ye, Huimin Wu, Yang Zhao, Lin Wu, Fangyu Wang

OncoTargets and Therapy · 2018 · 24 citations · 34 references

DOIFull text

Open access

Abstract

In conclusion, RTHF treatment inhibits colorectal tumor growth, decreases Wnt/β-catenin pathway activity, and downregulates target genes' expression.

References

34

Identification of stem cells in small intestine and colon by marker gene Lgr5

Nick Barker, Johan H. van Es, Jeroen Kuipers et al. · Nature · 2007 · 5.6K citations

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In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

Meritxell Huch, Craig Dorrell, Sylvia F. Boj et al. · Nature · 2013 · 1.5K citations · Full text

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Lineage Tracing Reveals Lgr5 <sup>+</sup> Stem Cell Activity in Mouse Intestinal Adenomas

Arnout Schepers, Hugo J.G. Snippert, Daniel E. Stange et al. · Science · 2012 · 1.1K citations

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Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex

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Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases

Jeremy Dupaul-Chicoine, Garabet Yeretssian, Karine Doiron et al. · Immunity · 2010 · 505 citations · Full text

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