Novel Approach with Controlled Nucleation and Growth for Green Synthesis of Size-Controlled Cyclodextrin-Based Metal–Organic Frameworks Based on Short-Chain Starch Nanoparticles

Abstract

In this study, the nano- and microsized cyclodextrin-based metal-organic frameworks (CD-MOFs) were successfully conducted using short-chain starch nanoparticles as seeds through the seed-mediated method. The morphology, size, crystal structure, thermal, and N₂ adsorption properties of CD-MOFs prepared at different time intervals were investigated. The scanning electron microscopy results showed that the size variation from nanometer to millimeter could be controlled by crystal growth time. The CD-MOFs based on short-chain starch nanoparticle had higher crystallinity and N₂ uptake, thus indicating that the method of seed-mediated was more facile and efficient than the previous approach. Resveratrol (Res) is a natural polyphenol compound that has anticancer and antimicrobial activities against several pathogens. However, this compound suffers from poor stability. trans-Res rapidly isomerizes when exposed under ultraviolet or visible light. The results showed that the stability of Res was substantially enhanced by its encapsulation in CD-MOF crystals.