Design, synthesis and biological evaluation of novel thiazolidinedione derivatives as irreversible allosteric IKK-β modulators

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Nobuko Futaki, Satoru Takahashi, Motofumi Yokoyama et al. · Prostaglandins · 1994 · 830 citations

Inflammation, Anti-inflammatory, Biochemistry +9

Mechanism-Based Inactivation of Human Cytochrome P450 Enzymes and the Prediction of Drug-Drug Interactions

R. Scott Obach, Robert L. Walsky, Karthik Venkatakrishnan · Drug Metabolism and Disposition · 2006 · 454 citations

Lipopolysaccharide-Induced Tumor Necrosis Factor Alpha Production by Human Monocytes Involves the Raf-1/MEK1-MEK2/ERK1-ERK2 Pathway

Tjomme van der Bruggen, Suzanne Nijenhuis, Estia van Raaij et al. · Infection and Immunity · 1999 · 266 citations · Full text

Signal Transduction Pathways, Apoptosis, Immunology +23

Inhibition of LPS-induced NO and PGE2 production by asiatic acid via NF-κB inactivation in RAW 264.7 macrophages: Possible involvement of the IKK and MAPK pathways

Kyung‐Jin Yun, Jiyeon Kim, Jongbin Kim et al. · International Immunopharmacology · 2007 · 249 citations

Inflammation, Pge2 Production, Cytokine +14

Lipopolysaccharide stimulation of ERK1/2 increases TNF-α production via Egr-1

Liang Shi, Raj Kishore, Megan R. McMullen et al. · American Journal of Physiology-Cell Physiology · 2002 · 143 citations

Immunology, Pathology, Cell Death +19