Concepedia

Engineering P450<sub>LaMO</sub>stereospecificity and product selectivity for selective C–H oxidation of tetralin-like alkylbenzenes

Ren‐Jie Li, Aitao Li, Jing Zhao, Qi Chen, Ning Li, Hui‐Lei Yu, Jian‐He Xu

Catalysis Science & Technology · 2018 · 19 citations · 51 references

DOI

Concepts

Abstract

<italic>Via</italic>Phe scanning based protein engineering, P450<sub>LaMO</sub>increased enantioselectivity to er 98 : 2 and product selectivity, alcohol : ketone, to ak 99 : 1.

References

51

Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes

Pedro S. Coelho, Eric M. Brustad, Arvind Kannan et al. · Science · 2012 · 828 citations

, , +15

Tuning P450 Enzymes as Oxidation Catalysts

Rudi Fasan · ACS Catalysis · 2012 · 396 citations

, , +17

Measurement of cytochrome P450 and NADPH–cytochrome P450 reductase

F. Peter Guengerich, Martha V. Martin, Christal D. Sohl et al. · Nature Protocols · 2009 · 385 citations · Full text

, , +14

Regio- and Enantioselective Alkane Hydroxylation with Engineered Cytochromes P450 BM-3

Matthew W. Peters, Peter Meinhold, Anton Glieder et al. · Journal of the American Chemical Society · 2003 · 333 citations

, , +17

Separate roles for FMN and FAD in catalysis by liver microsomal NADPH-cytochrome P-450 reductase.

J.L. Vermilion, David P. Ballou, Vincent Massey et al. · Journal of Biological Chemistry · 1981 · 297 citations · Full text

, , +12