<i>In vitro</i>and<i>in silico</i>analysis of the effects of<scp>D</scp>₂receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations

Abstract

Signal transduction and feedback are important determinants of the time course of drug effects. The effect of the D₂ receptor antagonist dissociation rate constant (k_off ) is limited to the maximal rate of fluctuations in dopamine signalling as determined by the dopamine k_off and the cAMP turnover.