Integration of Germline Pharmacogenetics Into a Tumor Sequencing Program

Abstract

Germline genotype determinations for <i>TPMT</i>, <i>DPYD</i>, and <i>CYP2C19</i> can be used to make evidence-based treatment recommendations in MI-Oncoseq patients. Although the proportion of patients for whom recommendations can be made is small, this added value to MI-Oncoseq and patient care comes at no additional genotyping cost. Pharmacogenetic assessment should be integrated into tumor sequencing programs that genotype matched germline DNA; however, the complexity and additional cost of implementing pharmacogenetics remain challenging.