Dynamic Changes and Drug-Induced Selection of Resistant Clones in a Patient With EGFR-Mutated Adenocarcinoma That Acquired T790M Mutation and Transformed to Small-Cell Lung Cancer

<i>MET</i> Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling

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<i>EGFR</i> Mutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib

Susumu Kobayashi, Titus J. Boggon, Tajhal Dayaram et al. · New England Journal of Medicine · 2005 · 3.9K citations · Full text

Medicine, Oncology, Pharmacology +15

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

Christopher Abbosh, Nicolai J. Birkbak, Gareth A. Wilson et al. · Nature · 2017 · 1.9K citations · Full text

Life Sciences, Molecular Biology, Oncology +13

PyClone: statistical inference of clonal population structure in cancer

Andrew Roth, Jaswinder Khattra, Damian Yap et al. · Nature Methods · 2014 · 1.1K citations · Full text

Medicine, Biostatistics, Oncology +14

Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors

Yong Jia, Cai‐Hong Yun, Eunyoung Park et al. · Nature · 2016 · 879 citations · Full text

Medicine, Oncology, Pharmacology +11