Discovery of novel selective GPR120 agonists with potent anti-diabetic activity by hybrid design

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

Da Young Oh, Saswata Talukdar, Eun Ju Bae et al. · Cell · 2010 · 2.4K citations · Full text

Inflammation, Obesity, Metabolic Syndrome +9

Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120

Akira Hirasawa, Keiko Tsumaya, Takeo Awaji et al. · Nature Medicine · 2004 · 1.5K citations

Molecular Physiology, Physiology, Free Fatty Acids +8

Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules

Celia P. Briscoe, Andrew J. Peat, Stephen C. McKeown et al. · British Journal of Pharmacology · 2006 · 395 citations · Full text

Cellular Physiology, Insulin Signaling, Molecular Pharmacology +20

The regulation of adipogenesis through GPR120

Chizu Gotoh, Yeon-Hee Hong, Tomoyo Iga et al. · Biochemical and Biophysical Research Communications · 2007 · 242 citations

Obesity, Metabolic Syndrome, Insulin Signaling +8

The Pharmacology of TUG-891, a Potent and Selective Agonist of the Free Fatty Acid Receptor 4 (FFA4/GPR120), Demonstrates Both Potential Opportunity and Possible Challenges to Therapeutic Agonism

Brian D. Hudson, Bharat Shimpukade, Amanda E. Mackenzie et al. · Molecular Pharmacology · 2013 · 197 citations · Full text