PPARγ in Complex with an Antagonist and Inverse Agonist: a Tumble and Trap Mechanism of the Activation Helix

Molecular basis of agonism and antagonism in the oestrogen receptor

A.M. Brzozowski, A.C.W. Pike, Zbigniew Dauter et al. · Nature · 1997 · 3.3K citations

Oestrogen Receptor, Molecular Pharmacology, Signal Transduction +12

The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen

Andrew K. Shiau, D. Barstad, Paula M. Loria et al. · Cell · 1998 · 2.7K citations · Full text

Endocrine Mechanism, Medicine, Hormonal Receptor +10

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ

Robert T. Nolte, G. Bruce Wisely, Stefan Westin et al. · Nature · 1998 · 1.9K citations

Signal Transduction, Biochemistry, Medicine +5

Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist

A.C.W. Pike · The EMBO Journal · 1999 · 968 citations · Full text

Signal Transduction, Biochemistry, Full Antagonist +10

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

Jang Hyun Choi, Alexander S. Banks, Jennifer L. Estall et al. · Nature · 2010 · 877 citations

Obesity, Metabolic Syndrome, Molecular Pharmacology +8