The CRISPR Journal · 2018 · 29 citations · 8 references
New TechnologiesEngineeringGeneticsMolecular BiologyGenomicsCrispr WorldGenome EngineeringCrisprOff-target EffectGenome SurgeryCrispr PlasmidsCrispr TechnologyBiotechnologySynthetic BiologyGenetic EngineeringGene EditingSystems BiologyMedicineGenome Editing
CRISPR technology has dramatically changed scientists' ability to conduct research in medicine, biotechnology, and agriculture through faster, more efficient genome editing. A key driver of the technology's adoption is the easy, fast, and inexpensive access to vectors and the resulting next-generation tools by the nonprofit plasmid repository Addgene. Since 2013, Addgene has shipped over 100,000 CRISPR plasmids to more than 75 countries worldwide. This pipeline of new technologies is enabling cutting-edge research to address the grand challenges of mankind.
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Multiplex Genome Engineering Using CRISPR/Cas Systems
Le Cong, F. Ann Ran, David Cox et al. · Science · 2013 · 15.4K citations
RNA-Guided Human Genome Engineering via Cas9
Prashant Mali, Luhan Yang, Kevin M. Esvelt et al. · Science · 2013 · 9.2K citations · Full text
CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes
Rodolphe Barrangou, Christophe Fremaux, Hélène Deveau et al. · Science · 2007 · 6.2K citations
RNA-programmed genome editing in human cells
Martin Jínek, Alexandra East, Aaron Cheng et al. · eLife · 2013 · 2.1K citations · Full text
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
Martin Jínek, Fuguo Jiang, David W. Taylor et al. · Science · 2014 · 1.2K citations · Full text