Concepedia

MCT1 regulates aggressive and metabolic phenotypes in bladder cancer

Guiming Zhang, Yongjian Zhang, Dahai Dong, Fangming Wang, Xiaocheng Ma, Fengju Guan, Lijiang Sun

Journal of Cancer · 2018 · 70 citations · 11 references

DOIFull text

Open access

Concepts

Abstract

Background: Monocarboxylate transporter isoform 1 (MCT1) is an important molecule in mediating lactate transportation. Recent studies have shown an oncogenic role of MCT1 in cancer development.

References

11

Cancer statistics, 2016

Rebecca L. Siegel, Kimberly D. Miller, Ahmedin Jemal · CA A Cancer Journal for Clinicians · 2016 · 16.2K citations · Full text

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The Plasma Membrane Lactate Transporter MCT4, but Not MCT1, Is Up-regulated by Hypoxia through a HIF-1α-dependent Mechanism

Mohammed S. Ullah, Andrew Davies, Andrew P. Halestrap · Journal of Biological Chemistry · 2006 · 868 citations · Full text

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CD147 subunit of lactate/H <sup>+</sup> symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

Renaud Le Floch, Johanna Chiche, Ibtissam Marchiq et al. · Proceedings of the National Academy of Sciences · 2011 · 413 citations

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Expression of lactate/H+ symporters MCT1 and MCT4 and their chaperone CD147 predicts tumor progression in clear cell renal cell carcinoma: immunohistochemical and The Cancer Genome Atlas data analyses

Younghye Kim, Jung-Woo Choi, Young Sik Kim · Human Pathology · 2014 · 113 citations

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CD147 regulates the expression of MCT1 and lactate export in multiple myeloma cells

Denise K. Walters, Bonnie K. Arendt, Diane F. Jelinek · Cell Cycle · 2013 · 85 citations · Full text

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