Concepedia

Expression of AGPAT2, an enzyme involved in the glycerophospholipid/triacylglycerol biosynthesis pathway, is directly regulated by HIF-1 and promotes survival and etoposide resistance of cancer cells under hypoxia

Eleni-Anastasia Triantafyllou, Eleni Georgatsou, Ilias Mylonis, George Simos, Efrosyni Paraskeva

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · 2018 · 71 citations · 35 references

DOI

Concepts

References

35

Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation

Karim Bensaad, Elena Favaro, Caroline A. Lewis et al. · Cell Reports · 2014 · 663 citations · Full text

, , +17

AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34

Anil K. Agarwal, Elif Arioǧlu, Salomé de Almeida et al. · Nature Genetics · 2002 · 518 citations

, , +6

HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma

Bo Qiu, Daniel Ackerman, Danielle J. Sanchez et al. · Cancer Discovery · 2015 · 407 citations · Full text

, , +17

Fatty Acid Synthase Gene Is Up-regulated by Hypoxia via Activation of Akt and Sterol Regulatory Element Binding Protein-1

Eiji Furuta, Sudha K. Pai, Rui Zhan et al. · Cancer Research · 2008 · 383 citations · Full text

, , +17

HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation Is Critical for Cancer Progression

De Huang, Tingting Li, Xinghua Li et al. · Cell Reports · 2014 · 356 citations · Full text

, , +17