Concepedia

3′-Modification stabilizes mRNA and increases translation in cells

Christian M. Gampe, Amy C. Seila White, S Nayak Siva, Frédéric J. Zécri, John L. Diener

Bioorganic & Medicinal Chemistry Letters · 2018 · 10 citations · 18 references

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18

Direct Gene Transfer into Mouse Muscle in Vivo

Jon A. Wolff, Robert W. Malone, Phillip Williams et al. · Science · 1990 · 4.2K citations

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N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice

Oliwia Andries, Séan Mc Cafferty, Stefaan C. De Smedt et al. · Journal of Controlled Release · 2015 · 679 citations · Full text

, , +11

Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation

Bart R. Anderson, Hiromi Muramatsu, Subba Rao Nallagatla et al. · Nucleic Acids Research · 2010 · 676 citations · Full text

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N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density

Yuri V. Svitkin, Yi Cheng, Tirtha Chakraborty et al. · Nucleic Acids Research · 2017 · 271 citations · Full text

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mRNA transcript therapy

Drew Weissman · Expert Review of Vaccines · 2014 · 223 citations

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