Séan Mc Cafferty

N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice

Oliwia Andries, Séan Mc Cafferty, Stefaan C. De Smedt et al. · Journal of Controlled Release · 2015 · 636 citations · Full text

Pseudouridine-incorporated Mrna, Immunology, N1-methylpseudouridine-incorporated Mrna +5

mRNA therapeutics deliver a hopeful message

Zifu Zhong, Séan Mc Cafferty, Francis Combes et al. · Nano Today · 2018 · 116 citations

Engineering, Rna Biology, Translational Research +8

Expression Kinetics and Innate Immune Response after Electroporation and LNP-Mediated Delivery of a Self-Amplifying mRNA in the Skin

Hanne Huysmans, Zifu Zhong, Joyca De Temmerman et al. · Molecular Therapy — Nucleic Acids · 2019 · 77 citations · Full text

Innate Immune System, Immunology, Immune Regulation +22

Immunogenicity and Protection Efficacy of a Naked Self-Replicating mRNA-Based Zika Virus Vaccine

Zifu Zhong, João Paulo Portela Catani, Séan Mc Cafferty et al. · Vaccines · 2019 · 70 citations · Full text

A dual-antigen self-amplifying RNA SARS-CoV-2 vaccine induces potent humoral and cellular immune responses and protects against SARS-CoV-2 variants through T cell-mediated immunity

Séan Mc Cafferty, A.K.M. Ashiqul Haque, Aster Vandierendonck et al. · Molecular Therapy · 2022 · 54 citations · Full text