Concepedia

A brain-enriched Drp1 isoform associates with lysosomes, late endosomes, and the plasma membrane

Kie Itoh, Yoshihiro Adachi, Tatsuya Yamada, Takamichi L. Suzuki, Takanobu Otomo, Heidi M. McBride, Tamotsu Yoshimori, Miho Iijima, Hiromi Sesaki

Journal of Biological Chemistry · 2018 · 77 citations · 27 references

DOIFull text

Open access

Concepts

Abstract

with lysosomes/late endosomes depends on lysosomal pH but not their protease activities. Thus, Drp1 may connect mitochondria to endosomal-lysosomal pathways in addition to mitochondrial division.

References

27

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

Naotada Ishihara, Masatoshi Nomura, Akihiro Jofuku et al. · Nature Cell Biology · 2009 · 1.1K citations

, , +14

Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-Driven Tumor Growth

Jennifer A. Kashatus, Aldo Nascimento, Lindsey J. Myers et al. · Molecular Cell · 2015 · 705 citations · Full text

, , +16

The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice

Junko Wakabayashi, Zhongyan Zhang, Nobunao Wakabayashi et al. · The Journal of Cell Biology · 2009 · 679 citations · Full text

, , +14

Endogenous Drp1 Mediates Mitochondrial Autophagy and Protects the Heart Against Energy Stress

Yoshiyuki Ikeda, Akihiro Shirakabe, Yasuhiro Maejima et al. · Circulation Research · 2014 · 567 citations · Full text

, , +17

Mitochondrial Fission and Fusion Factors Reciprocally Orchestrate Mitophagic Culling in Mouse Hearts and Cultured Fibroblasts

Moshi Song, Katsuyoshi Mihara, Yun Chen et al. · Cell Metabolism · 2015 · 476 citations · Full text

, , +16