Immunity · 2018 · 127 citations · 40 references
Life SciencesImmunologyMolecular BiologyCell PolarityCell SignalingSignal TransductionAffinity MaturationB Cell BiologyB Cell DevelopmentB Cell RegulationGerminal Center ReactionsHumoral ImmunityAntibody Affinity MaturationAntibody Production ImpairmentB Cell Metabolic ReprogrammingCell Polarity RegulationCellular Metabolic ReprogrammingDefective Cell PolarizationMtorc1 SignalingPlasma Cell Differentiation
B cells exhibited defective antigen polarization and mTORC1 signaling. While altered antigen polarization impaired antigen presentation and likely restricted the potential of GC development, defective mTORC1 signaling impaired metabolic reprogramming, mitochondrial remodeling, and heme biosynthesis in these cells, which altogether overwhelmingly opposed plasma cell differentiation. Taken together, our study reveals mechanistic insights into the function of PKCβ as a key regulator of B cell polarity and metabolic reprogramming that instructs B cell fate.
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The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation
Ruoning Wang, Christopher P. Dillon, Lewis Z. Shi et al. · Immunity · 2011 · 2.1K citations · Full text
Sequence analysis of peptides bound to MHC class II molecules
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