Modeling Late-Onset Sporadic Alzheimer’s Disease through BMI1 Deficiency

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki et al. · Cell · 2007 · 19.9K citations

Tissue Engineering, Regenerative Medicine, Defined Factors +14

Gene regulation and DNA damage in the ageing human brain

Tao Lu, Ying Pan, Shyan-Yuan Kao et al. · Nature · 2004 · 1.9K citations

Lifespan Extension, Dna Damage, Longevity +6

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

Jacqueline J.L. Jacobs, Karin Kieboom, Silvia Marino et al. · Nature · 1999 · 1.6K citations

Cell Regulation, Cell Division, Genetics +8

Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

Mason A. Israel, Shauna H. Yuan, Cédric Bardy et al. · Nature · 2012 · 1.2K citations

Neurodegenerative Diseases, Induced Pluripotent Stem Cell, Alzheimer's Disease +9

Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer's Disease

Gorazd B. Stokin, Concepción Lillo, Tomás L. Falzone et al. · Science · 2005 · 1.2K citations

Axonal Defects, Neurochemical Biomarkers, Cytoskeleton +20