The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Goberdhan P. Dimri, X Lee, George Basile et al. · Proceedings of the National Academy of Sciences · 1995 · 7.4K citations · Full text

Education, Cell Biology, Molecular Biology +15

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

Manuel Serrano, Athena W. Lin, Mila E. McCurrach et al. · Cell · 1997 · 5.1K citations · Full text

Medicine, Cell Biology, Oncology +10

Role of the INK4a Locus in Tumor Suppression and Cell Mortality

Manuel Serrano, Han‐Woong Lee, Lynda Chin et al. · Cell · 1996 · 1.6K citations · Full text

Medicine, Cancer Biology, Molecular Genetics +16

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

Takehiko Kamijo, Frédérique Zindy, Martine F. Roussel et al. · Cell · 1997 · 1.6K citations · Full text

Medicine, Genetics, Molecular Genetics +16

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

Frédérique Zindy, Christine M. Eischen, David H. Randle et al. · Genes & Development · 1998 · 1.2K citations · Full text

Life Sciences, Cell Biology, Genetics +17