Production of a breed of red sea bream Pagrus major with an increase of skeletal muscle mass and reduced body length by genome editing with CRISPR/Cas9

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

Martin Jínek, Krzysztof Chylinski, Ines Fonfara et al. · Science · 2012 · 17.3K citations · Full text

Life Sciences, Microbiology, Molecular Biology +17

PEAR: a fast and accurate Illumina Paired-End reAd mergeR

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Life Sciences, Bioinformatics, Genomic Data Analysis +15

Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member

Alexandra C. McPherron, Ann M. Lawler, Se‐Jin Lee · Nature · 1997 · 4K citations

Life Sciences, Molecular Biology, Physiology +14

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering

Haoyi Wang, Hui Yang, Chikdu Shivalila et al. · Cell · 2013 · 3.6K citations · Full text

Life Sciences, Genetics, Molecular Genetics +14

Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases

Sangsu Bae, Jeongbin Park, Jin‐Soo Kim · Bioinformatics · 2014 · 2.4K citations · Full text

Life Sciences, Biotechnology, Genetics +13