Novel substituted pyrazolone derivatives as AMP-activated protein kinase activators to inhibit lipid synthesis and reduce lipid accumulation in ob/ob mice

Nonalcoholic fatty liver disease: A spectrum of clinical and pathological severity☆, ☆☆

Christi A Matteoni, Zobair M. Younossi, T GRAMLICH et al. · Gastroenterology · 1999 · 3.4K citations · Full text

Medicine, Internal Medicine, Pathology +14

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

Jorge Henao‐Mejia, Eran Elinav, Chengcheng Jin et al. · Nature · 2012 · 2.4K citations

Life Sciences, Immunology, Pathology +12

Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

Barbara L. Cool, Bradley A. Zinker, William J. Chiou et al. · Cell Metabolism · 2006 · 918 citations · Full text

Medicine, Biochemistry, Pharmacology +14

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

Morgan D. Fullerton, Sandra Galić, Katarina Marcinko et al. · Nature Medicine · 2013 · 875 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade

Matthew J. Sanders, Pascal Grondin, Bronwyn D. Hegarty et al. · Biochemical Journal · 2007 · 668 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16