Improving the oral bioavailability of tapentadol via a carbamate prodrug approach: synthesis, bioactivation, and pharmacokinetics

(–)-(1 R,2 R)-3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)-phenol Hydrochloride (Tapentadol HCl): a Novel μ-Opioid Receptor Agonist/Norepinephrine Reuptake Inhibitor with Broad-Spectrum Analgesic Properties

Thomas Tzschentke, Thomas Christoph, Babette Kögel et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 394 citations

Medicine, Pharmacology, Pharmacotherapy +16

Biomolecular Modulation of Neurodegenerative Events during Ageing

Marcella Nebbioso, G. Scarsella, Aloisa Librando et al. · Oxidative Medicine and Cellular Longevity · 2015 · 283 citations · Full text

Life Sciences, Biochemistry, Nutritional Sciences +17

A randomized, double-blind, placebo-controlled phase 3 study of the relative efficacy and tolerability of tapentadol IR and oxycodone IR for acute pain

Stephen Daniels, Ed Casson, Jens‐Ulrich Stegmann et al. · Current Medical Research and Opinion · 2009 · 131 citations

Medicine, Orthopedic Surgery, Pharmacotherapy +17

Absorption, metabolism, and excretion of14C-labeled Tapentadol HCl in healthy male subjects

Rolf Terlinden, Joachim Ossig, Frank Fliegert et al. · European Journal of Drug Metabolism and Pharmacokinetics · 2007 · 107 citations

Pharmacy, Pharmacokinetics, Pharmacology +4

In vitro and in vivo characterization of tapentadol metabolites

Rolf Terlinden, Babette-Y. Kögel, Werner Englberger et al. · Methods and Findings in Experimental and Clinical Pharmacology · 2010 · 79 citations

Medicine, Pharmacokinetics, Pharmacology +17