Concepedia

Prodrug Bioavailability

Prodrug Bioavailability is the fraction and rate at which the active drug moiety, following enzymatic or chemical conversion from its pharmacologically inactive prodrug form, becomes available at the systemic circulation and target sites of action within the body.

76

Publications

2.5K

Citations

371

Authors

95

Institutions

Publications per year

2017–2026

11

Parents

Publications

76

Improved oral drug delivery: solubility limitations overcome by the use of prodrugs

David Fleisher, Ramon Bong, Barbra H. Stewart · Advanced Drug Delivery Reviews · 1996 · 129 citations

, , +14

The Fourth Molybdenum Containing Enzyme mARC: Cloning and Involvement in the Activation of<i>N</i>-Hydroxylated Prodrugs

Sanja Gruenewald, Bettina Wahl, Florian Bittner et al. · Journal of Medicinal Chemistry · 2008 · 109 citations

, , +17

Prodrugs of the selective antiherpesvirus agent 9-[4-hydroxy-3-(hydroxymethyl)but-1-yl]guanine (BRL 39123) with improved gastrointestinal absorption properties

Michael R. Harnden, Richard L. Jarvest, Malcolm R. Boyd et al. · Journal of Medicinal Chemistry · 1989 · 100 citations

, , +15

Pharmacokinetics, tissue distribution and excretion study of resveratrol and its prodrug 3,5,4′-tri-O-acetylresveratrol in rats

Liang Li, Xueying Liu, Qingwei Wang et al. · Phytomedicine · 2013 · 91 citations

, , +10

Characterization of in Vitro Biotransformation of New, Orally Active, Direct Thrombin Inhibitor Ximelagatran, an Amidoxime and Ester Prodrug

Bernd Clement, Katrin Lopian · Drug Metabolism and Disposition · 2003 · 89 citations

, , +14

1–5 of 76

Authors

371

  1. CL
    Claus Larsen

    University of Copenhagen, Denmark

    6 publications · 163 citations

    6

    h-index

  2. BC
    Bernd Clement

    Christian-Albrechts-Universität zu Kiel, Germany

    6 publications · 284 citations

    6

    h-index

  3. CD
    Cheng Der Yu

    University of Michigan, United States

    5 publications · 233 citations

    5

    h-index

  4. NF
    Norman F.H. Ho

    University of Michigan, United States

    5 publications · 233 citations

    5

    h-index

  5. JL
    Jeffrey L. Fox

    University of Utah, United States

    5 publications · 233 citations

    5

    h-index

1–5 of 371

Institutions

95

  1. University of Michigan

    Ann Arbor, United States

    9 h-index

    36 publications

    1.8K citations

  2. Schools of Visual Arts, The Royal Danish Academy of Fine Arts

    Copenhagen, Denmark

    8 h-index

    18 publications

    444 citations

  3. Christian-Albrechts-Universität zu Kiel

    Kiel, Germany

    6 h-index

    26 publications

    1.4K citations

  4. University of Eastern Finland

    Joensuu, Finland

    4 h-index

    21 publications

    664 citations

  5. AstraZeneca (Sweden)

    Södertälje, Sweden

    3 h-index

    7 publications

    195 citations

  6. Johns Hopkins University

    Baltimore, United States

    3 h-index

    30 publications

    1.1K citations

  7. University of Florida

    Gainesville, United States

    2 h-index

    3 publications

    125 citations

  8. Rabin Medical Center

    Petah Tikva, Israel

    2 h-index

    4 publications

    100 citations

1–8 of 95

Venues

  1. Journal of Pharmaceutical Sciences

    13 publications · 450 citations

    12

    h-index

  2. Journal of Medicinal Chemistry

    8 publications · 480 citations

    8

    h-index

  3. International Journal of Pharmaceutics

    7 publications · 181 citations

    7

    h-index

  4. Molecular Pharmaceutics

    4 publications · 76 citations

    4

    h-index

  5. Bioorganic & Medicinal Chemistry Letters

    3 publications · 77 citations

    3

    h-index

1–5