Concepedia

Regulation of CNKSR2 protein stability by the HECT E3 ubiquitin ligase Smurf2, and its role in breast cancer progression

Diana David, Arun Surendran, Jissa Vinoda Thulaseedharan, S. Asha Nair

BMC Cancer · 2018 · 19 citations · 26 references

DOIFull text

Open access

Abstract

Altogether, our findings reveal that Smurf2 is a novel positive regulator of CNKSR2 and suggest that Smurf2-CNKSR2 interaction may serve as a common strategy to control proliferation of human breast cancer cells by modulating CNKSR2 protein stability.

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