Concepedia

B-cell differentiation and IL-21 response in IL2RG/JAK3 SCID patients after hematopoietic stem cell transplantation

Alexandra Miggelbrink, Brent R. Logan, Rebecca H. Buckley, Roberta Parrott, Christopher C. Dvorak, Neena Kapoor, Hisham Abdel‐Azim, Susan E. Prockop, David C. Shyr, Hélène Decaluwe,

Blood · 2018 · 43 citations · 38 references

DOIFull text

Open access

Concepts

Abstract

Key Points IL2RG/JAK3-deficient B cells remain intrinsically defective posttransplant despite follicular helper T-cell reconstitution. In vitro response of B cells to IL-21 is a potential biomarker for humoral immunity in patients with IL2RG/JAK3 SCID after transplantation.

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