Concepedia

Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51

Shizhen Zhao, Wei Peng, Mengya Wu, Xiangqian Zhang, Liyu Zhao, Xiaolin Jiang, Chenzhou Hao, Xin Su, Dongmei Zhao, Maosheng Cheng

Bioorganic & Medicinal Chemistry · 2018 · 30 citations · 14 references

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How to bolster the antifungal pipeline

David W. Denning, Michael Bromley · Science · 2015 · 481 citations

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Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis

Tatiana Y. Hargrove, Laura Friggeri, Z. Wawrzak et al. · Journal of Biological Chemistry · 2017 · 408 citations · Full text

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Ergosterol Biosynthesis Inhibitors Become Fungicidal when Combined with Calcineurin Inhibitors against <i>Candida albicans</i> , <i>Candida glabrata</i> , and <i>Candida krusei</i>

Chiatogu Onyewu, Jill R. Blankenship, Maurizio Del Poeta et al. · Antimicrobial Agents and Chemotherapy · 2003 · 284 citations · Full text

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Effect of Antifungal Drugs on Cytochrome P450 (CYP) 2C9, CYP2C19, and CYP3A4 Activities in Human Liver Microsomes

Toshiro Niwa, Toshifumi Shiraga, Akira Takagi · Biological and Pharmaceutical Bulletin · 2005 · 271 citations · Full text

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The Clinical Candidate VT-1161 Is a Highly Potent Inhibitor of Candida albicans CYP51 but Fails To Bind the Human Enzyme

Andrew G. S. Warrilow, Claire M. Hull, Josie E. Parker et al. · Antimicrobial Agents and Chemotherapy · 2014 · 166 citations · Full text

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