Tatiana Y. Hargrove

Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis

Tatiana Y. Hargrove, Laura Friggeri, Z. Wawrzak et al. · Journal of Biological Chemistry · 2017 · 384 citations · Full text

Biosynthesis, Antifungal Agent, Biochemistry +8

Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) from Aspergillus fumigatus and Molecular Basis for the Development of Antifungal Drugs

Tatiana Y. Hargrove, Z. Wawrzak, David C. Lamb et al. · Journal of Biological Chemistry · 2015 · 145 citations · Full text

Structural Insights into Inhibition of Sterol 14α-Demethylase in the Human Pathogen Trypanosoma cruzi

Galina I. Lepesheva, Tatiana Y. Hargrove, Spencer Anderson et al. · Journal of Biological Chemistry · 2010 · 144 citations · Full text

Molecular Biology, Chemical Biology, Pharmaceutical Chemistry +16

Sterol 14α-Demethylase as a Potential Target for Antitrypanosomal Therapy: Enzyme Inhibition and Parasite Cell Growth

Galina I. Lepesheva, Robert Ott, Tatiana Y. Hargrove et al. · Chemistry & Biology · 2007 · 135 citations · Full text

Biochemistry, Antiparasitic Agent, Medicine +7

Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) from Leishmania infantum

Tatiana Y. Hargrove, Z. Wawrzak, Jialin Liu et al. · Journal of Biological Chemistry · 2011 · 120 citations · Full text

Pharmaceutical Science, Molecular Biology, Chemical Biology +21