Galina I. Lepesheva

Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis

Tatiana Y. Hargrove, Laura Friggeri, Z. Wawrzak et al. · Journal of Biological Chemistry · 2017 · 384 citations · Full text

Biosynthesis, Antifungal Agent, Biochemistry +8

Rational Modification of a Candidate Cancer Drug for Use Against Chagas Disease

James M. Kraus, Christophe L. M. J. Verlinde, Mandana Karimi et al. · Journal of Medicinal Chemistry · 2009 · 151 citations · Full text

Structure-Functional Characterization of Cytochrome P450 Sterol 14α-Demethylase (CYP51B) from Aspergillus fumigatus and Molecular Basis for the Development of Antifungal Drugs

Tatiana Y. Hargrove, Z. Wawrzak, David C. Lamb et al. · Journal of Biological Chemistry · 2015 · 145 citations · Full text

Structural Insights into Inhibition of Sterol 14α-Demethylase in the Human Pathogen Trypanosoma cruzi

Galina I. Lepesheva, Tatiana Y. Hargrove, Spencer Anderson et al. · Journal of Biological Chemistry · 2010 · 144 citations · Full text

Molecular Biology, Chemical Biology, Pharmaceutical Chemistry +16

The First Virally Encoded Cytochrome P450

David C. Lamb, Li Lei, Andrew G. S. Warrilow et al. · Journal of Virology · 2009 · 140 citations · Full text