Laura Friggeri

Structural analyses of Candida albicans sterol 14α-demethylase complexed with azole drugs address the molecular basis of azole-mediated inhibition of fungal sterol biosynthesis

Tatiana Y. Hargrove, Laura Friggeri, Z. Wawrzak et al. · Journal of Biological Chemistry · 2017 · 384 citations · Full text

Biosynthesis, Antifungal Agent, Biochemistry +8

Activity of caffeic acid derivatives against Candida albicans biofilm

Daniela De Vita, Laura Friggeri, Felicia Diodata D’Auria et al. · Bioorganic & Medicinal Chemistry Letters · 2014 · 74 citations

Antifungal Agent, Microbiology, Antimicrobial Compound +3

Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design

Tatiana Y. Hargrove, Laura Friggeri, Z. Wawrzak et al. · Journal of Lipid Research · 2016 · 58 citations · Full text

Sterol 14α-Demethylase Structure-Based Design of VNI ((<i>R</i>)-<i>N</i>-(1-(2,4-Dichlorophenyl)-2-(1<i>H</i>-imidazol-1-yl)ethyl)-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide)) Derivatives To Target Fungal Infections: Synthesis, Biological Evaluation, and Crystallographic Analysis

Laura Friggeri, Tatiana Y. Hargrove, Z. Wawrzak et al. · Journal of Medicinal Chemistry · 2018 · 45 citations · Full text

Structural Basis for Rational Design of Inhibitors Targeting <i>Trypanosoma cruzi</i> Sterol 14α-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its Inhibition

Laura Friggeri, Tatiana Y. Hargrove, Girish Rachakonda et al. · Journal of Medicinal Chemistry · 2014 · 44 citations · Full text

Drug Target, Chemical Biology, Chagas Disease +21